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Breast Cancer treatment details. Chemotherapy. Immunotherapy. University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States



Survival: ?
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
Immunotherapy
   
Drugs: Cytoxan
Paraplatin
Thioplex
Country: United States
   
City/State/Province: Chicago, Illinois
   
Hospital: University of Illinois at Chicago College of Medicine
   
Journal: Link
   
Date: 2/2001

Description:
Patients: This study involved 32 patients with advanced breast cancer.

Treatment: The treatment consisted of immunotherapy - interleukin-2 and G-CSF in combination with three chemotherapy drugs - carboplatin (paraplatin), thiotepa (thioplex), and cyclophosphamide (cytoxan). Some patients received interleukin-2 alone or in combination with G-CSF.

Toxicity: All patients experienced grade 1 to 2 toxicity in the form of flu-like symptoms including fever, chills, nausea and vomiting, and lightheadedness. Other toxicities included hypoxia and dyspnea. One patient had a grade 3 toxicity.

Results: Overall survival was not discussed but the authors stated that there was no statistical significance for overall survival favoring the patients who received interleukin-2 plus G-CSF over the patients receiving G-CSF only.

Support: This study was supported in part by a research grant from Amgen Clinical Research Division. Amgen markets interleukin-2.

Correspondence: Jeffrey A. Sosman, MD

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