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Breast Cancer treatment details. Chemotherapy. Gene Therapy. Georgetown University Medical Center, Washington, D.C., United States



Survival: N/R
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Gene Therapy
   
Drugs: Taxotere
Country: United States
   
City/State/Province: Washington, D.C.
   
Hospital: Georgetown University Medical Center
   
Journal: Link
   
Date: 8/2004

Description:
Patients: This Phase I study involved 22 patients with advanced breast cancer (10 patients) and other tumors (12 patients).

Treatment: The treatment consisted of Bcl-2 antisense (G3139 or Genasense) and the chemotherapy drug docetaxel (taxotere). Bcl-2 is a type of protein that is thought to make cells more resistant to apoptosis (programmed cell death) and Genasense targets this protein.

Toxicity: Grade 3-4 toxicities included fatigue, nausea/vomiting, anorexia, pleural effusion, neutropenia, and anemia.

Results: There were two objective responses in the breast cancer patients. Overall survival was not discussed.

Support: Support for this study was provided by Genta, Inc. and Aventis Pharmaceuticals. Genta manufactures Genasense. Taxotere is manufactured by Aventis.

Correspondence: J.L. Marshall, Inc.

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