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Breast Cancer treatment details. Gene Therapy. Wayne State University-Karmanos Cancer Institute, Detroit, Michigan, United States



Survival: ?
   
Toxicity Grade: 2
   
Treatments: Gene Therapy
   
Drugs:
Country: United States
   
City/State/Province: Detroit, Michigan
   
Hospital: Wayne State University-Karmanos Cancer Institute
   
Journal: Link
   
Date: 5/2001

Description:
Patients: This Phase I study involved 9 patients with recurrent and inoperable breast cancer and nine patients with head and neck cancer.

Treatment: The treatment consisted of intratumoral liposome E1A gene therapy. The E1A adenovirus gene is thought to act as a tumor inhibitor.

Toxicity: One breast cancer patient died of pneumonia which was not attributed to the treatment. Grade 2 toxicities included fever for the breast cancer patients.

Results: In one breast cancer patient there was no evidence of tumor from a biopsy taken from the tumor treatment site (during week 12 of the treatment). Overall survival was not discussed.

Support: This study was supported by a Targeted Genetics Corporation grant.

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