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Brain Cancer treatment details. Immunotherapy. Cedars-Sinai Medical Center, Los Angeles, California , United States



Survival: 14.9 months
   
Toxicity Grade:
   
Treatments: Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Los Angeles, California
   
Hospital: Cedars-Sinai Medical Center
   
Journal: Link
   
Date: 2/2001

Description:
Patients: This Phase I study involved seven patients with glioblastoma multiforme, and two patients with anaplastic astrocytoma.

Treatment: The treatment consisted of intradermal vaccination of peptide-pulsed dendritic cells. Peripheral blood dendritic cells were pulsed with peptides eluted from the surface of the patientís own tumor cells.

Toxicity: There were no serious adverse events or clinical or radiological evidence of autoimmune reaction in any patient. One patient developed a minor fever, nausea and vomiting. Another patient developed palpable lymph nodes which persisted for 2 months.

Results: The median survival times for the gliobalstoma multiforme patients who received this treatment was 455 days (14.9 months).

Correspondence: Keith Black, MD

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