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Prostate Cancer treatment details. Chemotherapy. The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States



Survival: 10.5 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Doxil
Platinol
Vepesid
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: The University of Texas M.D. Anderson Cancer Center
   
Journal: Link
   
Date: 7/2002

Description:
Patients: This Phase II study involved 38 patients with small-cell carcinoma of the prostate. The median age was 65 years

Treatment: The treatment consisted of three chemotherapy drugs – doxorubicin (doxil), etoposide (VP-16, vepesid), and cisplatin (platinol).

Toxicity: The authors described the therapy as “fairly toxic.” There were three deaths secondary to sepsis (infection). In addition, grade 4 toxicities included: hematologic, fatigue, nausea/vomiting, cardiovascular (thrombosis/pulomary embolism), small bowel obstruction, pancreatitis, and bilirubin.

Results: The median overall survival was 10.5 months (for the 36 assessable patients.)

Correspondence: Christos Papandreou, MD, PhD

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