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Prostate Cancer treatment details. Chemotherapy. Leon Berard , Lyon, France

Survival: 11.4 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Adrucil
Country: France
City/State/Province: Lyon
Hospital: Leon Berard
Journal: Link
Date: 8/2003

Patients: This Phase II randomized study involved 54 patients with hormone refractory metastatic prostate cancer. Patients were divided into two groups: Group 1 with 26 patients and Group 2 with 28 patients. For patients in Group 1, the median age was 68 and the median PSA was 85. For patients in Group 2, the median age was 68 and the median PSA was 254.

Treatment: For patients in Group 2, the treatment consisted of the chemotherapy drugs oxaliplatin (eloxatin) and 5-fluorouracil (5-FU).

Toxicity: For patients in Group 2, grade 3-4 toxicities included anemia, neutropenia, thrombocytopenia, vomiting, stomatitis, asthenia, and neurosensory.

Results: For patients in Group 2 the median overall survival was 11.4 months.

Support: The study was supported by a grant from Sanofi-Synthelabo. This company manufactures oxaliplatin (eloxatin).

Correspondence: Dr. S. Mackenzie

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