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Brain Cancer treatment details. Chemotherapy. Radiation. London Regional Cancer Center, London, Ontario, Canada

Survival: 9.7 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Hycamtin
Country: Canada
City/State/Province: London, Ontario
Hospital: London Regional Cancer Center
Journal: Link
Date: 2/2001

Patients: This Phase I trial included 47 patients with glioblastoma multiforme.

Treatment: The treatment consisted of a chemotherapy drug, topotecan (hycamtin) plus cranial radiation.

Toxicity: One objective of this Phase I study was to document the acute and delayed treatment-related toxicities of topotecan administered at three different doses. At the highest dose (1.5 mg/m2/d) there was grade 4 neutropenia and leucopenia.

Results: Median survival for all patients was 9.7 months. There was no apparent difference in survival by topotecan dose schedule.

Correspondence: Barbara Fisher, MD

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