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Prostate Cancer treatment details. Chemotherapy. Hormone. University of Michigan School of Medicine, Ann Arbor, Michigan, United States

Survival: 16.4 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Cytoxan
Country: United States
City/State/Province: Ann Arbor, Michigan
Hospital: University of Michigan School of Medicine
Journal: Link
Date: 10/2003

Patients: This Phase II trial involved 37 patients with hormone refractory (androgen independent) prostate cancer. Median age was 66 years and median PSA was 63 (range 1.1 2021).

Treatment: The treatment consisted of chemotherapy cyclophosphamide, hormone therapy diethylstilbestrol (an estrogen), and prednisone.

Toxicity: Four patients experienced cardiovascular toxicity myocardial infarction (1 patient), popliteal DVT (1 patient), a clot in a abdominal aortic aneurysm graft (1 patient), and paroxysmal atrial fibrillation (1 patient). Other grade 3-4 toxicities included lymphopenia.

Results: The overall median survival was 16.4 months.

Correspondence: David C. Smith, MD

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