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Prostate Cancer treatment details. Biologic therapy. University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, United States



Survival: 16.0 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Madison, Wisconsin
   
Hospital: University of Wisconsin Comprehensive Cancer Center
   
Journal: Link
   
Date: 9/2003

Description:
Patients: This Phase II study involved 26 patients with advanced androgen-independent (hormone refractory) prostate cancer. Median age was 70 years. Twenty-one patients had bone metastasis. Nine patients had previous radiation therapy.

Treatment: The treatment consisted of 1 alpha-hydroxyvitamin D2 (a vitamin D analogue).

Toxicity: Toxicities included hypercalcemia (grade 1-3), and increased creatinine (grade 1-2).

Results: Median survival was 487 days (16 months).

Support: Support for the study was provided by Bone Care International. This company is involved in the development and marketing of 1 alpha-hydroxyvitamin D2.

Correspondence: Glenn Liu, MD

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