Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Brain Cancer treatment details. Chemotherapy. Radiation. University of California San Francisco, San Francisco, California, United States



Survival: 9.7 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: San Francisco, California
   
Hospital: University of California San Francisco
   
Journal: Link
   
Date: 1/2001

Description:
Patients: This study included 231 patients with newly diagnosed glioblastoma multiforme. (Six patients were later determined to have a gliosarcoma.) The patients were divided into four treatment groups.

1. Group A – Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy. Administered to 57 patients.
2. Group B – Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy plus DFMO. Administered to 57 patients.
3. Group C – Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy. Administered to 58 patients.
4. Group D - Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy plus DFMO. Administered to 59 patients.

Treatment: Group B – Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy plus DFMO.

Toxicity: In Group B, there was grade 3 or 4 myelosuppression in two patients and grade 3 ototoxicity in 2 patients.

Results: Overall survival for this treatment (Group B) was 42 weeks (i.e. 9.7 months). The authors noted that “no benefit is noted when the polyamine inhibitor DFMO is used concurrently with standard or accelerated fractionated radiation therapy.”

Correspondence: M. Prados, MD

E-mail to a Friend Email Physician More Information