Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results

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Breast Cancer treatment details. Chemotherapy. Texas Oncology, Dallas, Texas, United States

Survival: 12.7 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Taxol
Country: United States
City/State/Province: Dallas, Texas
Hospital: Texas Oncology
Journal: Link
Date: 8/2005

Patients: This Phase III study involved 449 women with advanced breast cancer, of whom 394 were assessed. All patients had previously received an anthracycline-containing chemotherapy regimen. The patients were randomly assigned to two groups. Group B had 224 women (205 assessable) with a median age of 54. These women had a median number of two metastatic sites and relapsed at 20 months (median) after the beginning of their last treatment.

Treatment: In Group B, the treatment consisted of one chemotherapeutic agent: paclitaxel.

Toxicity: In Group B, Grade 3-4 toxicities were observed in 121 patients, including neutropenia, anemia, thrombocytopenia, asthenia, neurosensory toxicity, myalgia, and pain.

Results: The median overall survival was 12.7 months for Group B. Complete or partial responses were observed in 72 Group A patients and 56 Group B patients. The authors concluded for their study, "docetaxel ... demonstrated superior efficacy compared with paclitaxel ... , providing significant clinical benefit in terms of survival and time to disease progression, with a numerically higher response rate and manageable toxicities."

Support: Aventis Pharmaceuticals financially supported this study, and many of the authors have been employees or consultants. Many authors also disclosed holding stock, receiving research funding, or receiving honoraria from Aventis. Aventis manufactures and markets docetaxel.

Correspondence: Steve E. Jones, MD

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