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Brain Cancer treatment details. Radiation. University of California San Francisco, San Francisco, California, United States



Survival: 8.5 months
   
Toxicity Grade:
   
Treatments: Radiation
   
Drugs:
Country: United States
   
City/State/Province: San Francisco, California
   
Hospital: University of California San Francisco
   
Journal: Link
   
Date: 1/2001

Description:
Patients: This study included 231 patients with newly diagnosed glioblastoma multiforme. (Six patients were later determined to have a gliosarcoma.) The patients were divided into four treatment groups.

1. Group A Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy. Administered to 57 patients.
2. Group B Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy plus DFMO. Administered to 57 patients.
3. Group C Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy. Administered to 58 patients.
4. Group D - Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy plus DFMO. Administered to 59 patients.

Treatment: Group C Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy.

Toxicity: In Group C, there were no grade 3 or 4 toxicities noted for this group. Lesser toxicities were not detailed.

Results: Overall survival for group C was 37 weeks (i.e. 8.5 months).

Correspondence: M. Prados, MD

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