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Rectal Cancer treatment details. Chemotherapy. Institut Gustave Roussy, Villejuif, France



Survival: 27.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Eloxatin
Country: France
   
City/State/Province: Villejuif
   
Hospital: Institut Gustave Roussy
   
Journal: Link
   
Date: 8/2005

Description:
Patients: This Phase II study involved 28 patients with metastatic colorectal cancer with inoperable liver metastases. Seventeen patients were men, and eleven were women. The median age was 60.

Treatment: The treatment consisted of three chemotherapy drugs: Oxaliplatin, fluorouracil, and leucovorin.

Toxicity: Grade 3-4 toxicities included neutropenia, leucopenia, thrombocytopenia, and diarrhea. Other toxicities included nausea/vomiting, infection, neurotoxicity, and mucositis.

Results: The median overall survival was 27 months.

Support: Sanofi-Aventis Pharmaceuticals finally supported this study, and three authors previously received honoraria. Sanofi-Aventis manufactures and markets oxaliplatin.

Correspondence: Michel Ducreux, MD, PhD

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