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Brain Cancer treatment details. Chemotherapy. Nova Scotia Cancer Centre, Halifax, Nova Scotia, Canada



Survival: N/R
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
   
Drugs:
Country: Canada
   
City/State/Province: Halifax, Nova Scotia
   
Hospital: Nova Scotia Cancer Centre
   
Journal: Link
   
Date: 4/2005

Description:
Patients: This Phase II trial involved 18 patients; 16 had recurrent glioblastoma, and 2 had recurrent anaplastic astrocytoma. There were 14 men and 4 women, and the median age was 62. All patients previously received surgery, radiotherapy, and no more than one chemotherapeutic treatment.

Treatment: The treatment consisted of one chemotherapeutic drugs: T138067-sodium. This experimental compound interferes with cell division.

Toxicity: The following grade 1-3 toxicities were reported: granulocytoma, white blood cell deficiency, fatigue, gastrointestinal, and neurological.

Results: No responses were seen and three patients achieved a median overall survival of 2.6 months. The trial was terminated. The authors concluded that "T138067-sodium showed no evidence of objective antitumor activity in this population...".

Correspondence: Sarah Kirby, MD

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