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Brain Cancer treatment details. Chemotherapy. Radiation. Philipps-Universitaet Marburg, Marburg, Germany



Survival: 15.0 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs: Hycamtin
Country: Germany
   
City/State/Province: Marburg
   
Hospital: Philipps-Universitaet Marburg
   
Journal: Link
   
Date: 4/2005

Description:
Patients: This trial involved 60 patients with newly diagnosed glioblastoma multiforme (GBM). There were 41 men and 19 women, and the mean age was 56 years. All patients had surgery prior to treatment.

Treatment: The treatment consisted of radiotherapy and one chemotherapeutic drug: topotecan.

Toxicity: Two patients died of infectious complications while undergoing therapy. Grade 3-4 toxicities included aberrant motor functions, consciousness, mucostitis, and hematological.

Results: The median overall survival was 15 months.

Support: Smith Kline Beecham provided both technical and logistical support for this project. Smith Kline Beecham manufactures and markets topotecan.

Correspondence: Markus W. Gross, MD

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