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Brain Cancer treatment details. Chemotherapy. Immunotherapy. Radiation. Surgery. Nihon University School of Medicine, Tokyo, Japan



Survival: 13.0 months
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
Immunotherapy
Radiation
Surgery
   
Drugs:
Country: Japan
   
City/State/Province: Tokyo
   
Hospital: Nihon University School of Medicine
   
Journal: Link
   
Date: 3/2005

Description:
Patients: This trial involved 58 patients: 22 had anaplastic astrocytoma, and 36 had glioblastoma multiforme. Thirty-four patients were men, and twenty-four were women. Overall, the median age was 53 years.

Treatment: The treatment consisted of surgery, radiation therapy, the immunotherapeutic agent human interferon beta (IFN-b), and the chemotherapeutic agent nimustine hydrochloride.

Toxicity: No grade 4 toxicities were reported. Grade 3 toxicities included neutropenia.

Results: The median overall survival was 16 months. For anaplastic astrocytoma patients, the median survival was 58 months. For glioblastoma multiforme patients, the median survival was 13 months. The authors concluded that post-surgery interferon-nimustine-radiation treatment may have therapeutic benefit for anaplastic astrocytoma patients.

Correspondence: Takao Watanabe, MD

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