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Brain Cancer treatment details. Chemotherapy. Radiation. Johns Hopkins, Baltimore, Maryland, United States

Survival: 11.0 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: BCNU, BiCNU
Country: United States
City/State/Province: Baltimore, Maryland
Hospital: Johns Hopkins
Journal: Link
Date: 4/2003

Patients: In the experimental arm of this Phase III study, there were 109 Patients with newly diagnosed supratentorial glioblastoma multiforme (one patient was classified as having a gliosarcoma and one patient was classified as having a mixed high grade astrocytoma).

Treatment: Infusional carmustine (BiCNU) and cisplatin (platinol) and radiation therapy.

Toxicity: 91% of patients experienced grade 3-5 toxicities. There were three treatment related deaths grade 5 (cardiac, infection, pulmonary embolism). Grade 3-4 toxicities included: myelosuppression, nausea, vomiting, metabolic and phlebitis.

Results: The median survival time was 11.0 months.

Correspondence: Stuart A. Grossman, MD

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