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Brain Cancer treatment details. Biologic therapy. Radiation. Duke University Medical Center, Durham, N.C., United States

Survival: 18.2 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Durham, N.C.
Hospital: Duke University Medical Center
Journal: Link
Date: 6/2005

Patients: This Phase II trial involved 33 patients with malignant gliomas including: 27 with glioblastoma multiforme, 4 with anaplastic astrocytoma, and 2 with anaplastic oligodendroglioma. Twenty-three were men, and ten were women. The average age was 49 years.

Treatment: The treatment involved a radiolabeled agent - (131)I-labeled anti-tenascin murine 81C6 monoclonal antibody that was administered directly into a surgically created resection cavity. 29 patients also received radiation therapy and 28 patients also received adjuvant chemotherapy.

Toxicity: Grade 4 hematologic toxicities were observed in patients that received a higher whole-body radiologic dosage. Grade 3-4 irreversible neurologic toxicity was also observed.

Results: The overall survival was 18.2 months (79 weeks) for the glioblastoma patients.

Correspondence: Michael R. Zalutsky, PhD

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