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Kidney Cancer treatment details. Biologic therapy. University of Kansas Medical Center, Kansas City, KS, United States

Survival: 9.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Kansas City, KS
Hospital: University of Kansas Medical Center
Journal: Link
Date: 7/2005

Patients: This Phase II study involved 38 patients with advanced renal cell carcinoma. Thirty-four patients were considered eligible - 22 men and 12 women. Twenty-four patients had prior nephrectomies.

Treatment: The treatment consisted of flavopiridol, a cyclin-dependent kinase inhibitor that prevents cell cycle progression and tumor growth.

Toxicities: Grade 4 toxicities included: dyspnea, hyperglycemia, neutropenia, and granulocytopenia. In addition, there were two thrombotic events: one pulmonary embolism and one deep venous thrombosis.

Results: The median survival was 9 months.

Correspondence: P.J. Van Veldhuizen, MD

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