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Kidney Cancer treatment details. Immunotherapy. Beth Israel Deaconess Medical Center, Boston, MA, United States



Survival: 17.5 months
   
Toxicity Grade: 4
   
Treatments: Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Beth Israel Deaconess Medical Center
   
Journal: Link
   
Date: 1/2005

Description:
Patients: This Phase III study involved a total of 192 patients with metastatic renal cell carcinoma. Patients were divided into two groups of 96 patients each. Each group was administered a different therapy.

Treatment: For Group A, the treatment consisted of high-dose interleukin-2 (IL-2). For Group B, the treatment consisted of subcutaneous IL-2 plus interferon.

Toxicities: Grade 3 and 4 toxicities for group A included: constitutional, hypotension gastrointestinal, hematologic, neurologic, cardiac, pulmonary, renal/electrolytes, psychiatric, hepatic, and infection.

Results: Median survival was 17 months for Group A.

Support: Several of the study's authors have acted as consultants, performed contract work for, or received more than $2,000/year from Chiron or Schering. Chiron markets IL-2. Schering markets interferon.

Correspondence: David F. McDermott, MD

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