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Lung Cancer treatment details. Biologic therapy. Chemotherapy. San Filippo Neri Hospital, Rome, Italy

Survival: 11.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Taxol
Country: Italy
City/State/Province: Rome
Hospital: San Filippo Neri Hospital
Journal: Link
Date: 5/2005

Patients: This Phase II study involved 58 patients with non-small cell lung cancer. Forty-four patients were men, fourteen were women, and the median age was 60. Over 50% of the patients had adenocarcinoma. The other types were epidermoid, brohioloalveolar and undifferentiated.

Treatment: The treatment consisted of two drugs. One was a chemotherapy agent called paclitaxel and the other was Cox-2 inhibitor called celecoxib (Celebrex). Celebrex is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID).

Toxicity: Grade 4 toxicities included neutropenia, leucopenia, and diarrhea. Other toxicities included: peripheral neuropathy, allergic reactions, fatigue and anemia.

Results: Median overall survival was 11 months.

Support: This study was supported in part by a grant from the CORE Project by Pfizer. Pfizer markets and/or manufactures Celebrex.

Correspondence: Giampietro Gasparini, MD

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