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Brain Cancer treatment details. Chemotherapy. Radiation. Surgery. University Hospital Eppendorf, Hamburg, Germany



Survival: 13.5 months
   
Toxicity Grade:
   
Treatments: Chemotherapy
Radiation
Surgery
   
Drugs: BCNU, BiCNU
Country: Germany
   
City/State/Province: Hamburg
   
Hospital: University Hospital Eppendorf
   
Journal: Link
   
Date: 4/2003

Description:
Patients: This Phase III study involved 240 patients, half of whom received the BCNU (gliadel) wafer. Of the 120 patients who received the wafer, 101 had glioblastoma multiforme, 13 had anaplastic gliomas, and 6 had other types of cancer (primary brain or metastasis to brain).

Treatment: Carmustine (BCNU) wafers and radiation therapy.

Toxicity: Toxicities included: abnormal gait, amnesia, aphasia, ataxia, brain edema, confusion, convulsion, depression, dizziness, facial paralysis, grand mal convulsions, hemiplegia, incoordination, intracranial hypertension, neuropathy, and speech disorder. Toxicity grades were not used.

Results: Median survival for the BCNU (gliadel) wafer-treated glioblastoma multiforme patients was 13.5 months.

Support: This study was sponsored and funded by Guilford Pharmaceuticals. Guilford Pharmaceuticals markets gliadel wafers.

Correspondence: Manfred Westphal, MD

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