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Melanoma treatment details. Chemotherapy. Immunotherapy. Campus Benjamin Franklin, Berlin, Germany



Survival: 9.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Immunotherapy
   
Drugs: DTIC-Dome
Platinol
Country: Germany
   
City/State/Province: Berlin
   
Hospital: Campus Benjamin Franklin
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase III study involved a total of 363 patients with metastatic melanoma who were divided into two groups: Group A of 180 patients and Group B of 183 patients. For Group B the median age was 48.

Treatment: The treatment for Group B consisted of two chemotherapy agents (Dacarbazine and Cisplatin) and two immunotherapy agents (interferon-alpha-2b and interleukin-2).

Toxicity: Grade 4 toxicities for this group included: dyrhythmias, cardiovascular dysfunction, hyper or hypotension, various gastrointestinal toxicities, neuropathy, and pulmonary. There were also grade 3-4 hematologic toxicities.

Results: The median overall survival was 9 months.

Support: Several of the authors had received consulting, honorarian or research funding from Schering Plough. This company markets interferon-alpha-2b.

Correspondence: Ulrich Keilholz, MD

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