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Melanoma treatment details. Immunotherapy. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy



Survival: 19.2 months
   
Toxicity Grade:
   
Treatments: Immunotherapy
   
Drugs:
Country: Italy
   
City/State/Province: Milan
   
Hospital: Istituto Nazionale per lo Studio e la Cura dei Tumori
   
Journal: Link
   
Date: 10/2005

Description:
Patients: This Phase II study involved 38 pretreated metastatic melanoma patients, of which 20 received at least one or two complete cycles of treatment.

Treatment: The treatment consisted of immunotherapy (autologous, tumor-derived heat shock protein gp96-peptide complex vaccine) administered with interferon-alpha.

Toxicity: Toxicities were not graded but consisted of erythema, induration, nausea, vertigo, fatigue, vomiting, malaise, fever and pain and itching at the injection site.

Results: The median overall survival was 19.2 months (583 days) for the 20 patients who received at least one or two complete cycles of treatment.

Support: The study was supported by Antigenics, a company that markets personal cancer vaccines.

Correspondence: Giorgio Parmiani, MD

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