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Melanoma treatment details. Chemotherapy. Immunotherapy. Beth Israel Deaconess Medical Center, Boston, Mass, United States



Survival: 7.5 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Immunotherapy
   
Drugs: Platinol
Temodar
Country: United States
   
City/State/Province: Boston, Mass
   
Hospital: Beth Israel Deaconess Medical Center
   
Journal: Link
   
Date: 10/2002

Description:
Patients: This Phase II study involved 48 patients with metastatic melanoma.

Treatment: The treatment consisted of chemotherapy (cisplatin, vinblastine, temozolomide) and immunotherapy (interleukin 2 and interferon-alpha 2B).

Toxicity: Significant toxicities included 2 deaths from cardiac events. Grade 3-4 toxicities included neutropenia, thrombocytopenia, renal insufficiency, and nausea/vomiting.

Results: The overal median survival was 7.5 months.

Support: The study was supported by grants from Amgen, Chiron, and Schering Plough. Chiron markets or manufactures interleukin-2 and Schering markets or manufactures interferon-alpha2B and temozolomide.

Correspondence: Michael B. Atkins, MD

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