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Melanoma treatment details. Biologic therapy. University of Chicago Cancer Research Center, Chicago, Ill, United States



Survival: 6.7 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Chicago, Ill
   
Hospital: University of Chicago Cancer Research Center
   
Journal: Link
   
Date: 6/2004

Description:
Patients: This Phase II study involved 31 patients with advanced melanoma.

Treatment: The treatment consisted of a biological therapy - the Flk-1 tyrosine kinase inhibitor SU5416.

Toxicity: The study mentions a patient who died of a pulmonary embolus, and one who died after discharge from the hospital to treat dehydration. But, these deaths were not associated with the treatment by the authors. Grade 3-4 toxicities included: hematological, hyperglycemia, nausea, vomiting, elevated LFT's, infection, fatigue/weakness, and bleeding/thrombosis.

Results: The overal median survival was 6.7 months (29 weeks).

Support: The study was supported by Pharmacia. This company manufactures or markets progenipoietin.

Correspondence: Thomas F. Gajewski, MD

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