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Melanoma treatment details. Biologic therapy. Pascale National Cancer Institute, Naples, Italy

Survival: N/R
Toxicity Grade: 2
Treatments: Biologic therapy
Country: Italy
City/State/Province: Naples
Hospital: Pascale National Cancer Institute
Journal: Link
Date: 10/2005

Patients: This Phase I study involved 15 patients with metastatic melanoma.

Treatment: The treatment consisted of a biological therapy - pegylated arginine deiminase used to lower plasma arginine.

Toxicity: There were no grade 3-4 toxicities directly attributable to the drug. Grade 1-2 toxicities included: hypotension and clinical laboratory abnormalities.

Results: There were no responses and overall survival was not reported.

Support: Several of the authors were employed by Phoenix Pharmacologics. Pegylated arginine deiminase (Hepacid) is made by Phoenix Pharmacologics.

Correspondence:John S. Bomalaski, MD

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