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Melanoma treatment details. Biologic therapy. Pascale National Cancer Institute, Naples, Italy



Survival: N/R
   
Toxicity Grade: 2
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Naples
   
Hospital: Pascale National Cancer Institute
   
Journal: Link
   
Date: 10/2005

Description:
Patients: This Phase I study involved 15 patients with metastatic melanoma.

Treatment: The treatment consisted of a biological therapy - pegylated arginine deiminase used to lower plasma arginine.

Toxicity: There were no grade 3-4 toxicities directly attributable to the drug. Grade 1-2 toxicities included: hypotension and clinical laboratory abnormalities.

Results: There were no responses and overall survival was not reported.

Support: Several of the authors were employed by Phoenix Pharmacologics. Pegylated arginine deiminase (Hepacid) is made by Phoenix Pharmacologics.

Correspondence:John S. Bomalaski, MD

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