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Ovarian Cancer treatment details. Biologic therapy. Stanford University Medical Center, Stanford, CA, United States



Survival: N/R
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Stanford, CA
   
Hospital: Stanford University Medical Center
   
Journal: Link
   
Date: 1/2004

Description:
Patients: This phase II study involved 36 women with advanced ovarian cancer. The median age was 57.

Treatment: The treatment involved one biological agent - an antisense oligonucleotide inhibitor of protein kinase C alpha called aprinocarsen.

Toxicity: Grade 4 toxicities included nausea and throbocytopenia.

Results: There were no responses seen on scans, but one patient had a decline in serum CA 125 levels.

Support: Support was provided by ISIS pharmaceuticals. ISIS manufactures or markets aprinocarsen.

Correspondence: Branimir I. Sikic, MD

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