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Ovarian Cancer treatment details. Biologic therapy. National Cancer Institute, Bethesda, MD , United States



Survival: N/R
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Bethesda, MD
   
Hospital: National Cancer Institute
   
Journal: Link
   
Date: 12/2003

Description:
Patients: This phase II study involved 36 patients with relapsed epithelial ovarian cancer.

Treatment: The treatment involved one biologic agent called carboxyamidotriazole (CAI). CAI is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. It is thought to inhibit angiogenesis, tumor growth, invasion, and metastasis.

Toxicity: Grade 3 toxicities included fatigue, vomiting, neutropenic fever, and neutropenia.

Results: No overall survival was determined.

Correspondence: Elise C. Kohn, MD

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