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Prostate Cancer treatment details. Chemotherapy. Georges Pompidou European Hospital, Paris, France

Survival: 18.6 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Emcyt
Country: France
City/State/Province: Paris
Hospital: Georges Pompidou European Hospital
Journal: Link
Date: 5/2005

Patients: This Phase II study enrolled 130 men, who were randomized into three groups. Group A had 44 men (median age 68) with hormonal-resistant prostate cancer. For all patients, metastatic sites involved up to two organs and included bone and lymph node tissue.

Treatment: The treatment for group A involved three chemotherapeutic agents: docetaxel (intravenous), estramustine (oral), and prednisone.

Toxicities: Grade 3-4 toxicities in group A included granulocytopenia, diarrhea, thrombosis, nausea, vomiting, and anemia.

Results: In group A, one patient died due to complications from diabetes (previously diagnosed). The overall median survival for group A was 18.6 months.

Support: Authors of this study had been employees, consultants, or honorarium recipients for Aventis. Aventis manufactures and/or markets docetaxel.

Correspondence: Stephane Oudard, MD.

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