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Prostate Cancer treatment details. Chemotherapy. Georges Pompidou European Hospital, Paris, France



Survival: 18.4 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Emcyt
Taxotere
Country: France
   
City/State/Province: Paris
   
Hospital: Georges Pompidou European Hospital
   
Journal: Link
   
Date: 5/2005

Description:
Patients: This Phase II study enrolled 130 men, who were randomized into three groups. Group B had 42 men (median age 68) with hormonal-resistant prostate cancer. In 39 patients, metastatic sites involved up to two organs; the remaining three patients had metastatic sites in three or more organs. Metastatic sites included bone and lymph node tissue.

Treatment: The treatment for group B involved three chemotherapeutic agents: docetaxel (intravenous), estramustine (oral), and prednisone.

Toxicities: Grade 3-4 toxicities in group B included thrombocytopenia and thrombosis.

Results: For group B, the overall median survival was 18.4 months.

Support: Authors of this study had been employees, consultants, or honorarium recipients for Aventis. Aventis manufactures docetaxel.

Correspondence: Stephane Oudard, MD.

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