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Brain Cancer treatment details. Chemotherapy. Dokkyo University School of Medicine, Mibu, , Tochighi,, Japan



Survival: 9.4 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Paraplatin
Vepesid
Country: Japan
   
City/State/Province: Tochighi,
   
Hospital: Dokkyo University School of Medicine, Mibu,
   
Journal: Link
   
Date: 12/2002

Description:
Patients: A total of 28 patients were enrolled in this Phase II study. There were fourteen anaplastic astrocytoma patients whose tumors have recurred and fourteen patients with recurring glioblastoma multiforme.

Treatment: The treatment consisted of two chemotherapy drugs, carboplatin (paraplatin) and etoposide (vepesid).

Toxicity: Toxicities were mainly hematological, gastrointestinal, and hepatic. In 167 courses of therapy there was one instance of grade 4 leucopenia, and three instances of grade 4 thrombocytopenia. (There were 17 instances of grade 3 leucopenia and 4 instances of grade 3 thrombosytopenia.)

Results: There were no complete responses. The time from recurrence to death was 9.4 months for the glioblastoma multiforme patients.

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