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Prostate Cancer treatment details. Hormone. Indiana University, Indianapolis, IN, United States



Survival: ?
   
Toxicity Grade: 3
   
Treatments: Hormone
   
Drugs:
Country: United States
   
City/State/Province: Indianapolis, IN
   
Hospital: Indiana University
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase II study involved 33 patients with hormone-refractory prostate cancer. The median age was 74 years. All but one patient had bone metastases.

Treatment: The treatment consisted of an estrogen derivative: 2-Methoxyestradiol. The patients were separated into two groups and given a low or high dose of 2-methoxyestradiol.

Toxicity: There were no grade-4 toxicities. Grade 3 toxicities include elevated liver enzymes.

Results: The median overall survival was not reported, but the higher-dose group was associated with a longer time on therapy. The authors concluded, "2-methoxyestradiol is well tolerated with evidence of anticancer activity at the 1,200 mg/d dose."

Support: EntreMed provided financial support for this study, and several of the authors are employees of EntreMed. EntreMed manufactures and markets 2-methoxyestradiol.

Correspondence: Christopher Sweeney, MD

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