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Prostate Cancer treatment details. Biologic therapy. Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD, United States

Survival: 19.0 months
Toxicity Grade: 3
Treatments: Biologic therapy
Country: United States
City/State/Province: Bethesda, MD
Hospital: Warren Grant Magnuson Clinical Center, NIH
Journal: Link
Date: 3/2005

Patients: This Phase II study involved 72 men with hormone refractory malignant prostate cancer with bone metastases. The patients were randomly divided into two groups. Group A had 36 patients with a median age of 70.

Treatment: For Group A, the treatment consisted of one drug: ketoconazole which is an antifungal medication.

Toxicity: No grade 4-5 toxicities were observed. For Group A, grade 1-3 toxicities included fatigue, hyperglycemia, and duodenal ulcer.

Results: Group A's median survival was 19 months, while group B's median survival was not determined. However, there were no significant difference between the response rates, progression-free survival, and overall survival between Group A and Group B.

Correspondence: William D. Figg, MD

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