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Prostate Cancer treatment details. Chemotherapy. Princess Margaret Hospital, Ontario, Canada

Survival: N/R
Toxicity Grade: 3
Treatments: Chemotherapy
Country: Canada
City/State/Province: Ontario
Hospital: Princess Margaret Hospital
Journal: Link
Date: 9/2005

Patients: This Phase II study involved 40 men with hormone resistent prostate cancer. 21 patients had prior radiation therapy and 26 had prior hormone therapy. Metastatic sites included bone, liver, lung, and lymph nodes.

Treatment: The treatment consisted of a chemotherapy drug Gefitinib (Iressa).

Toxicity: Grade 1-3 toxicities included fatigie. Grade 1-2 toxicities included: anorexia, diarrhea, nausea, stomatitis, taste disturbance, and rash.

Results: None of the patients demonstrated a PSA or objective measurable response. The median overall survival was not reported.

Support: The study was supported by AstraZeneca Pharmaceuticals and the NCI of Canada. AstraZeneca manufactures and/or markets Gefitinib.

Correspondence: Malcolm J. Moore, MD

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