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Prostate Cancer treatment details. Biologic therapy. University of Colorado Cancer Center, Denver, CO, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs: Herceptin
Country: United States
   
City/State/Province: Denver, CO
   
Hospital: University of Colorado Cancer Center
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase II study involved 18 men with hormone resistent prostate cancer. 13 had bone metastases.

Treatment: The treatment consisted of a biological therapy - Trastuzumab (Herceptin) which is a monoclonal antibody that is typically used to treat breast cancer.

Toxicity: 17% of patients experienced grade 4 toxicities. The authors did not list the grade 4 toxicities but mentioned a grade 3 cardiac toxicity and provided a list of 24 toxicities without specifying the grades (i.e. fatigue, nausea, dizziness, syncope, dyspnea, edema, chest pain, palpitations, etc.)

Results: The median overall survival was not reported and the authors concluded that Trastuzumab (Herceptin) as a single agent demonstrated poor efficacy in treating Hormone Refractory Prostate Cancer.

Correspondence: Albaha Barqawi, MB, FRCS

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