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Lung Cancer treatment details. Chemotherapy. University General Hospital of Heraklion, Crete, Greece

Survival: 7.8 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Camptosar
Country: Greece
City/State/Province: Crete
Hospital: University General Hospital of Heraklion
Journal: Link
Date: 10/2005

Patients: This Phase II study involved 139 patients with advanced non-small-cell lung cancer. All patients were treated previously with taxanes and gemcitabine. The patients were randomized into two groups. Group A had 71 patients (64 men, 7 women) with a median age of 61 years.

Treatment: For Group A, treatment consisted of two chemotherapeutic agents: irinotecan and cisplatin.

Toxicity: For Group A, grade 3-4 toxicities include neutropenia, diarrhea, thrombocytopenia, nausea/vomiting, and asthenia.

Results: For Group A (irinotecan and cisplatin), the median overall survival was 7.8 months. For Group B (cisplatin-only), the median overall survival was 8.8 months. The authors concluded, "The irinotecan and cisplatin regimen did not confer a survival benefit compared with cisplatin as second-line treatment of patients with advanced NSCLC pretreated with a taxane/gemcitabine regimen, despite its better efficacy in terms of response rate."

Correspondence: Dr. V. Georgoulias

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