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Lung Cancer treatment details. Chemotherapy. Radiation. University Hospital, St. Etienne, France



Survival: 14.5 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs: Navelbine
Platinol
Country: France
   
City/State/Province: St. Etienne
   
Hospital: University Hospital
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase III study involved 201 patients with advanced non-small-cell lung cancer who were randomly assigned into two groups. Group A had 91 men and 10 women with a median age of 56 years.

Treatment: Treatment consisted of radiotherapy and two chemotherapeutic agents: cisplatin and vinorelbine. Group A was given a "sequential" schedule of chemotherapy and radiotherapy. Group B was given a concurrent schedule.

Toxicity: In Group A, there were six reported treatment related deaths. Other grade 3-4 toxicities included neutropenia, anemia, thrombocytopenia, infection, nausea/vomiting, pneumonitis, and esophagitis.

Results: For Group A, the median overall survival was 14.5 months. For Group B, the median overall survival was 16.3 months. There was an observed trend in decreased relapse rate and increased survival for Group B (concurrent treatment) patients after 2 years.

Correspondence: Pierre Fournel, MD

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