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Lung Cancer treatment details. Chemotherapy. Radiation. University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States



Survival: 13.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs: Paraplatin
Taxol
Country: United States
   
City/State/Province: Pittsburgh, PA
   
Hospital: University of Pittsburgh Cancer Institute
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase II/III study involved 276 patients with advanced non-small-cell lung cancer who were randomly assigned into three groups. Group A had 91 patients (63 men, 28 women); eighteen patients were over 70 years old.

Treatment: The treatment consisted of radiotherapy and two chemotherapeutic agents: carboplatin and paclitaxel. Group A received chemotherapy followed by radiotherapy.

Toxicity: Chemotherapeutic toxicities: grade 3-4 chemotherapeutic-specific toxicities included granulocytopenia, leukopenia, nausea/vomiting, and hyperglycemia. Radiotherapeutic toxicities for Group A included: grade 3-4 lung, neurologic, cardiac, anemia, and esophagitis toxicities.

Results: The median overall survival for this group was 13.0 months.

Support: Bristol Meyers Squibb financially supported this study, and several authors have disclosed financial relationships with Bristol Meyers Squibb. Bristol Meyers Squibb manufactures and/or markets paclitaxel and carboplatin.

Correspondence: Chandra P. Belani, MD

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