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Lung Cancer treatment details. Chemotherapy. Radiation. University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States



Survival: 12.7 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs: Paraplatin
Taxol
Country: United States
   
City/State/Province: Pittsburgh, PA
   
Hospital: University of Pittsburgh Cancer Institute
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase II/III study involved 276 patients with advanced non-small-cell lung cancer who were randomly assigned into three groups. Group B had 74 patients (54 men, 20 women); twenty-one patients were over 70 years old.

Treatment: The treatment consisted of radiotherapy and two chemotherapeutic agents: carboplatin and paclitaxel. Group B received induction chemotherapy followed by both chemotherapy and radiotherapy.

Toxicity: There was one treatment related death in this group from infection. Other Chemotherapeutic toxicities included: grade 3-4 granulocytopenia, leukopenia, nausea/vomiting, and hyperglycemia. Radiotherapeutic toxicities for Group B included: leukopenia, esophagitis, granulocytopenia, thrombocytopenia, nausea/vomiting, neurologic, and anemia.

Results: The median overall survival for this group was 12.7 months.

Support: Bristol Meyers Squibb financially supported this study, and several authors have disclosed financial relationships with Bristol Meyers Squibb. Bristol Meyers Squibb manufactures and/or markets paclitaxel and carboplatin.

Correspondence: Chandra P. Belani, MD

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