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Lung Cancer treatment details. Chemotherapy. Radiation. Vanderbilt University Medical Center, Nashville, TN, United States

Survival: 20.6 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Paraplatin
Country: United States
City/State/Province: Nashville, TN
Hospital: Vanderbilt University Medical Center
Journal: Link
Date: 9/2005

Patients: This Phase II study involved 51 patients with locally advanced (stage IIIA or IIIB) non–small-cell lung cancer. Thirty-four patients were men, and seventeen were women. The mean age was 58 years.

Treatment: The treatment consisted of two chemotherapy agents (paclitaxel and carboplatin) and thoracic radiation with efaproxiral (a drug that acts as a radiation sensitizer).

Toxicity: Grade 3-4 toxicities included hypoxemia, radiation pneumonitis, and fatigue.

Results: The median overall survival was 20.6 months.

Support: Allos Therapeutics financially supported this study, and several of the authors are employees, consultants, or honoraria recipients. Allos Therapeutics manufactures and/or markets efaproxiral.

Correspondence: Hak Choy, MD

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