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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Surgery. University of Padova, Padova, Italy

Survival: 18.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Platinol
Country: Italy
City/State/Province: Padova
Hospital: University of Padova
Journal: Link
Date: 6/2003

Patients: This Phase II study involved 46 patients treated for peritoneal carcinomatosis from colon adenocarcinoma.

Treatment: Thirty-four patients were treated with complete cytoreductive surgery immediately followed by intraoperative hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) with mitomycin C and cisplatin.

Toxicity: Three patients had intra-abdominal complications (two abdominal abscesses and one hemoperitoneum), which required reoperation. Pleural effusion or pneumonia was recorded in four cases. According to the modified Ozolsí classification, grade I, II, III, and IV locoregional toxicity was observed in 18, 3, 1, and 1 patient, respectively. Hematological toxicity (grade I or II anemia, according to the World Health Organization classification) occurred in four cases.

Results: The median overall survival was 18 months.

Correspondence: Carlo Riccardo Rossi, MD

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