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Breast Cancer treatment details. Chemotherapy. M.D. Anderson Cancer Center, Houston, Texas, United States



Survival: 14.7 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Taxol
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: M.D. Anderson Cancer Center
   
Journal: Link
   
Date: 9/2005

Description:
Patients: This Phase II study involved 63 women with advanced metastatic breast cancer. The mean age was 48.2 years. Forty-five women were from Indian-Eastern descent, while fourteen were Caucasian. Metastatic sites included lung, liver, and bone. Only sixteen patients did not receive chemotherapy prior to treatment.

Treatment: The treatment consisted of one agent: ABI-007, which is a nanoparticle containing a biologically interactive albumin-bound form of paclitaxel.

Toxicity: One patient died as a result of possibly treatment-related
cardiac ischemia/infarction. Grade 3-4 toxicities included neutropenia, leukopenia, anemia, fatigue, sensory neuropathy, myalgia, and diarrhea.

Results: The median overall survival was 14.7 months (63.6 weeks). Two patients had a complete response, and 28 had a partial response to treatment. The authors concluded that the ABI-007 form of paclitaxel "allows for safe administration of high paclitaxel doses without premedication, resulting in significant antitumor activity in patients with MBC, including those receiving the drug as first-line therapy."

Correspondence: Nuhad K. Ibrahim, MD

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