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Breast Cancer treatment details. Biologic therapy. Chemotherapy. University of Munich, Munich, Germany

Survival: 18.8 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Gemzar
Country: Germany
City/State/Province: Munich
Hospital: University of Munich
Journal: Link
Date: 12/2005

Patients: This Phase II study involved 20 women with HER2-overexpressing metastatic breast cancer. All patients received chemotherapy before the study. The median age was 52.5 years. Metastatic sites were predominantly visceral.

Treatment: The treatment consisted of two chemotherapeutic agents - gemcitabine and cisplatin, and a biological therapy - trastuzumab (a monoclonal antibody).

Toxicity: Grade 3-4 toxicities included thrombocytopenia, leukopenia, anemia, nausea/vomiting, and neurotoxicity.

Results: The median overall survival was 18.8 months. Eight patients partially responded to treatment, and eight patients achieved stable disease.

Correspondence: Dr H. J. Stemmler

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