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Rectal Cancer treatment details. Biologic therapy. Chemotherapy. Centre Rene Gauducheau, Nantes, France

Survival: 18.2 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Eloxatin
Country: France
City/State/Province: Nantes
Hospital: Centre Rene Gauducheau
Journal: Link
Date: 1/2006

Patients: This Phase II study involved 64 patients with metastatic colorectal cancer (49 patients had colon cancer and 15 patients had rectal cancer.) Thirty-six patients were men, and twenty-eight were women. The median age was 68 years. Metastatic sites frequently involved lung and liver.

Treatment: The treatment consisted of three chemotherapeutic agents: uracil, ftorafur, and oxaliplatin. In addition a vitamin leucovorin (folate) was also administered.

Toxicity: Grade 3-4 toxicities included sensory neuropathy, thrombocytopenia, asthenia, diarrhea, infection, and neutropenia.

Results: The median overall survival was 18.2 months. One complete response and twenty partial responses were observed, with twenty-nine patients achieving stable disease.

Correspondence: Dr. J. Bennouna

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