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Rectal Cancer treatment details. Chemotherapy. Radiation. C.R.O. National Cancer Institute, Aviano, Italy



Survival: ?
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
Radiation
   
Drugs: Xeloda
Country: Italy
   
City/State/Province: Aviano
   
Hospital: C.R.O. National Cancer Institute
   
Journal: Link
   
Date: 11/2005

Description:
Patients: This Phase II study involved 53 patients with locally advanced, resectable, rectal cancer. Thirty-nine patients were men, fourteen were women, and median age was 63 years.

Treatment: The treatment consisted of one chemotherapeutic agent: capecitabine. Radiation therapy was also administered.

Toxicity: Grade 1-3 toxicities included leukopenia, thrombocytopenia, anemia, diarrhea, and proctitis.

Results: The median overall survival was not reported. Thirty-one patients responded to treatment (2 complete, 29 partial), and twenty-two achieved stable disease. The authors concluded, "Preoperative chemoradiation with capecitabine and RT appeared to be effective in locally advanced
resectable, rectal cancer."

Correspondence: Dr A. De Paoli

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