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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Cancer Therapy and Research Center, San Antonio TX, United States

Survival: ?
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Camptosar
Country: United States
City/State/Province: San Antonio TX
Hospital: Cancer Therapy and Research Center
Journal: Link
Date: 12/2005

Patients: This Phase I study involved 20 patients with metastatic colorectal cancer.

Treatment: The treatment consisted of one biologic agent (oblimersen, which is an antisense oligonucleotide directed to the Bcl-2 mRNA) and one chemotherapeutic agent (irinotecan).

Toxicity: Grade 3-4 toxicities included neutropenia, thrombocytopenia, anemia, lymphopenia, and diarrhea.

Results: One patient experienced a partial response and 10 additional patients had stable disease lasting 2.510 months. Median survival was not reported.

Correspondence: Dr A. W. Tolcher

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