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Colon Cancer treatment details. Biologic therapy. Vanderbilt University Medical Center, Nashville TN, United States



Survival: 6.3 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Nashville TN
   
Hospital: Vanderbilt University Medical Center
   
Journal: Link
   
Date: 12/2005

Description:
Patients: This Phase II study involved 110 patients with metastatic colorectal cancer. The patients were randomized into two groups. Group A had 55 patients (36 men, 19 women; 48 Caucasian, 3 African-American, 1 Hispanic, 1 Asian) with a median age of 60 years. Group B has 55 patients (37 men, 18 women; 48 Caucasian, 7 African-American) with a median age of 60 years. Metastatic sites included liver and lung.

Treatment: The treatment consisted of one biological therapy agent: gefitinib. Gefitinib inhibits an enzyme (tyrosine kinase).

Group A received half of the dose that Group B received.

Toxicity: Grade 1-4 toxicities included abdominal pain, neutropenia, diarrhea, fatigue, skin rash, and anorexia.

Results: The median overall survival was 6.3 months for all patients (5.2 months for Group A and 8.2 months for Group B). The authors concluded, "Gefitinib is inactive as a single agent in patients with previously treated colorectal cancer."

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