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Brain Cancer treatment details. Chemotherapy. Radiation. Surgery. Western Pennsylvania Cancer Institute, Pittsburg, Pennsylvania, United States



Survival: 14.9 months
   
Toxicity Grade:
   
Treatments: Chemotherapy
Radiation
Surgery
   
Drugs: BCNU, BiCNU
Country: United States
   
City/State/Province: Pittsburg, Pennsylvania
   
Hospital: Western Pennsylvania Cancer Institute
   
Journal: Link
   
Date: 8/2002

Description:
Patients: This study involved 270 patients (subjects in the “Valid Study Group”) divided into two groups. Group 1 contained 137 patients. Of these 137 patients, 123 had newly diagnosed glioblastoma multiforme. The other 14 had an anaplastic glioma or a mixed glioma. Group 2 contained 133 patients. Of these 133 patients, 107 had newly diagnosed glioblastoma multiforme. The other 26 had an anaplastic glioma or a mixed glioma.

Treatment: The treatment for Group 2 included: surgery, external beam radiation therapy, interstial radiotherapy boost (radioactive isotope 125I) and the chemotherapy drug BCNU.

Toxicity: Not discussed, however necrosis was found in 11 patients and was considered not a treatment failure, but a result of therapy.

Results: For Group 2, the median survival for glioblastoma multiforme patients was 64.0 weeks (14.9 months).

Correspondence: Robert G. Selker, MD

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