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Ovarian Cancer treatment details. Chemotherapy. Dana Farber/Partners Cancer Care Program, Boston, Mass, United States

Survival: ?
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United States
City/State/Province: Boston, Mass
Hospital: Dana Farber/Partners Cancer Care Program
Journal: Link
Date: 4/2006

Patients: This phase II trial involved 74 patients with epithelial ovarian cancer. Patients were separated into two groups - 58 women with platinum-resistant disease and 16 with platinum-sensitive disease. The overall median age was 57.

Treatment: Patients received intravenous irofluven. Irofluven is a derivative of a highly toxic molecule isolated from the Jack O'Lantern mushroom.

Toxicity: Toxicities included: grade 4 anorexia, nausea, thrombocytopenia and significant retinal toxicity.

Results: Overall median survival was not reported. There were only two documented responses (one for 3 months and one for 5 months). This study found that irofluven had limited antitumor activity (with these patients).

Support: The study was supported by a grant from MGI PHARMA Inc. This company manufactures and/or markets irofluven.

Correspondence: Dr. Michael Seiden

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